Research within the Department of Emergency Medicine is a core mission of our Department. The research mission overlaps and supports the other department missions of patient care, education and faculty development. The research mission engages faculty, fellows, residents, students and research staff.
Mark Angelos, MD
Andy Chen, PhD
Mahmood Khan, PhD
The department has a long standing laboratory research effort initially lead by Dr. Charles Brown from 1985-1995 and subsequently led by Dr. Angelos. Since 1995, we have trained 1 post-doc and 9 research fellows and graduate students, three of whom obtained their PhD and 3 of whom obtained their Master’s Degree. In 2012, we successfully recruited Dr. Andy Chen, a NIH
funded investigator and in 2013 we recruited a new research scientist, Dr. Mahmoud Khan who comes with partial NIH
support. We currently have 2 large, well-resourced laboratories located in the Davis Heart Lung Research Institute
. Our laboratory research program focuses on cardiac injury, specifically redox regulation of CV disease, ischemia reperfusion injury, oxygen therapy and cardiac regenerative cell therapy. Contact Individual: Dr. Angelos
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Jeffrey Caterino, MD
Thomas Terndrup, MD
Howard Werman, MD
Lauren Southerland, MD
Ashish Panchal, MD
Michael Hill, RN
Student Research Assistant
In recent years we have built up a strong clinical research program led by Dr. Jeffrey Caterino. This staff provides project management, subject enrollment, IRB assistance, and statistical support to clinical investigators and ongoing clinical studies in the Department. Through our collaboration with Neurology, we now can provide around-the-clock enrollment of subjects for clinical trials.
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The clinical research program in The OSU Department of Emergency Medicine engages in a variety of NIH, foundation, and industry funded trials in addition to supporting the research efforts of departmental faculty and trainees. Some currently active protocols in the Department include:
Expanding Antimicrobial Stewardship: A prospective, observational cohort study funded by the NIH National Institute on Aging to develop an antimicrobial stewardship program based on the use of health information technology for patients presenting to the ED from a long-term care facility. This study aims to improve diagnostic accuracy and correct prescribing of antimicrobials.
Cardiac MRI Strategy for the Management of Patients with Acute Chest Pain and Detectable to Elevated Troponin (CMR-IMPACT): A randomized clinical study funded by the NIH National Heart Lung and Blood Institute and led by Dr. Jeffrey Caterino at OSU in collaboration with Dr. Chadwick Miller (Principal Investigator) from Wake Forest University Health Sciences. This study aims to determine the optimum management strategy for patients with intermediate to high-risk acute chest pain. A cardiac MRI-guided strategy will be tested as an alternative to invasive management strategies in detecting significant coronary disease and the need for coronary revascularization.
Procalcitonin Antibiotic Consensus Trial (ProACT): A randomized, multi-center study funded by the NIH National Institutes of General Medical Sciences and led by Dr. Lauren Southerland at OSU in collaboration with Dr. David Huang (Principal Investigator) from the University of Pittsburgh. This study is designed to investigate the effect of implementing a novel procalcitonin guideline on antibiotic use and adverse outcomes in ED patients with lower-respiratory tract infections.
Improving Syncope Risk Stratification in Older Adults: A multi-center, prospective, observational cohort study funded by the NIH National Heart Lung and Blood Institute and led by Dr. Jeffrey Caterino at OSU in collaboration with Dr. Benjamin Sun (Principal Investigator) from Oregon Health & Science University. This study gathers information for the development of a novel risk-based predication model to increase clinical benefit and reduce cost compared to existing care of older adults who present to the ED with syncope.
Measuring the effect of Ohio's Geriatric Trauma Triage Criteria: Using the Ohio Trauma Registry and funded by the Ohio Department of Public Safety, Dr. Jeffrey Caterino is investigating the effects of the Ohio Geriatric Trauma Triage Criteria on outcomes in injured older adults.
Care of Older Adults with Fragility Fractures in the ED (COFFEe): COFFEe is a pilot study led by Dr. Lauren Southerland at OSU to identify and prevent ongoing morbidity and maintain independence after fragility fractures in older adults.
Neurological Emergencies Treatment Trials Network (NETT):
NETT was created by the NIH to conduct large trials to reduce the burden of very acute injuries and illnesses affecting the nervous system from a variety of pathologies ranging from stroke to traumatic brain injury to seizures to meningitis. Emergency Medicine at OSU participates in NETT in collaboration with the Department of Neurology and Dr. Michel Torbey (OSU NETT PI). More information can be found here: http://www.nett.umich.edu/nett/welcome
StrokeNet was created by the NIH to conduct small and large clinical trials and research studies to advance acute stroke treatment, stroke prevention, and recovery and rehabilitation following a stroke. The Department of Emergency Medicine at OSU participates in StrokeNet in collaboration with the Department of Neurology and Dr. Michel Torbey (OSU StrokeNet PI). More information can be found here: https://www.nihstrokenet.org/
Prevention and Early Treatment of Acute Lung Injury (PETAL):
The Clinical Trials Network for PETAL is a network of 12 Clinical Centers and 1 Clinical Coordinating Center funded by the NIH National Heart, Lung, and Blood Institute to develop and conduct randomized controlled trials in Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). Emergency Medicine (Dr. Thomas Terndrup, site PI) and Critical Care at OSU will be collaborating in the upcoming PETAL studies. More information can be found here: http://petalnet.org/general-public
Industry-sponsored studies: The Department has a long history of successful participation in industry-sponsored trials. Currently active protocols include investigations of novel agents to reverse the anticoagulant effects of newer anticoagulant medications and the development of new rapid nasal swabs for influenza.
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David Bahner, MD
Diane Gorgas, MD
Sorabh Khandelwal, MD
Nicholas Kman, MD
Daniel Martin, MD
Education Research Specialist
In addition to our laboratory and clinical research programs, we have a core group of faculty educators in our department who are engaged in educational research. Dr. Sorabh Khandelwal
and Dr. Nick Kman
are focused on Education of Medical students and Dr. Dan Martin
and Dr. Diane Gorgas
with the residency leadership team our examining teaching methods in residency learning. Dr. David Bahner
leads a nationally recognized program surrounding ultrasound education. These educational research areas represent important avenues of research for our specialty. If interested in educational research involvement, please contact the lead individuals for each area.
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Finally, there are always opportunities for faculty, residents, and students to engage in non-funded clinical research projects to address interesting clinical questions which frequently arise in the practice of emergency medicine. These projects frequently serve to help residents meet their graduation scholarly project requirement. For assistance in these projects please contact Dr. Caterino
to coordinate support efforts.
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The future of research in the Department of Emergency Medicine is bright. We are strongly committed to growing this mission over the next years in conjunction with the College of Medicine’s goal to increase our research standing. Both our laboratory and clinical research programs currently receive NIH funding, which we anticipate will continue to grow. As our research mission grows, we are anxious to recruit additional research core faculty and provide research training opportunities to our students, residents and fellows.
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The Department of Emergency Medicine has a long history of both intra- and inter-institutional collaboration. With over 120,000 patient visits per year between our two clinical sites, we have a large and diverse patient population. We are constantly seeking opportunities to expand our research mission and actively seek out additional potential collaborators both within and outside of our institution. Clinical research studies conducted within the emergency department at Ohio State are expected to have Emergency Medicine faculty input and involvement. We encourage potential collaborators to contact us early in their study design to ensure effective collaboration.